A new differentiation factor from culture media of the HL-60 cell line treated with retinoic acid. Isolation and primary structure determination
Kostanian, I.A.; Astapova, M.V.; Starovoĭtova, E.V.; Dranitsyna, S.M.; Lipkin, V.M.
Bioorganicheskaia Khimiia 21(4): 243-248
1995
ISSN/ISBN: 0132-3423 PMID: 7786314 Document Number: 449362
A new 8.2-kDa protein factor was isolated from cell culture of a promyelocyte leukemic HL-60 cell line that exhibited a differentiation-inducing effect upon the initial cell line. The primary structure of this factor was determined by sequencing the protein (N-terminal region) and the corresponding cDNA. A molecule of the differentiation factor secreted by HL-60 cells consisted of 54 amino acid residues and was glycosylated.
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