The effect of antidepressants on the indices of the cardiointervalogram in intact rats and during the deprivation of paradoxical sleep
Arushenian, A.E.; Semenova, F.O.; Fedulova, I.V.
Eksperimental'naia i Klinicheskaia Farmakologiia 58(2): 29-31
1995
ISSN/ISBN: 0869-2092 PMID: 7773084 Document Number: 449328
The acute and chronic administration of antidepressants (amitriptyline, imipramine, befol) to rats led to the sympathetic influences of a cardiointervalogram as reduced cardiointervals and its increased amplitude and tension index. Imipramine was found to be effective in eliminating disadaptational abnormalities in cardiac performance, which promoted REM-sleep deprivation.