Post-coital contraceptive efficacy of the seeds of Nigella sativa in rats
Keshri, G.; Singh, M.M.; Lakshmi, V.; Kamboj, V.P.
Indian Journal of Physiology and Pharmacology 39(1): 59-62
1995
ISSN/ISBN: 0019-5499 PMID: 7705872 Document Number: 448924
Hexane extract of the seeds of Nigella sativa L. prevented pregnancy in Sprague-Dawley rats treated orally at 2 g/kg daily dose on days 1-10 post-coitum. Significant antifertility activity was also observed in its column fractions and subfractions. At contraceptive dose, the active hexane extract exhibited only mild uterotrophic activity comparable almost to 0.002 mg/kg dose of 17-Ethinylestradiol, but was devoid of any estrogenicity in the immature rat bioassay.