Low CD4 lymphocyte count in a patient with P. carinii pneumonia after autologous bone marrow transplantation
Castagnola, E.; Dini, G.; Lanino, E.; Tasso, L.; Dallorso, S.; Garaventa, A.; Rossi, G.A.; Giacchino, R.
Bone Marrow Transplantation 15(6): 977-978
1995
ISSN/ISBN: 0268-3369 PMID: 7581100 Document Number: 448876
A case is reported in a 5-yr-old girl from Italy who developed fever, dry cough and progressive dyspnoea following a bone marrow transplant. Lymphocyte subpopulation analysis showed that 5% CD4+ lymphocytes with an absolute count of 5/ml. Chest radiography demonstrated bilateral infiltrates and Pneumocystis carinii was identified in bronchoalveolar lavage samples. The patient was treated with cotrimoxazole and steroids, but after initial improvement her condition deteriorated. She died with pulmonary fibrosis but without P. carinii in her lungs.
Document emailed within 1 workday
Related Documents
Lyytikäinen, O.; Ruutu, T.; Volin, L.; Lautenschlager, I.; Jokipii, L.; Tiittanen, L.; Ruutu, P. 1996: Late onset Pneumocystis carinii pneumonia following allogeneic bone marrow transplantation Bone Marrow Transplantation 17(6): 1057-1059Singer, C.R.; Tansey, P.J.; Burnett, A.K. 1983: T lymphocyte reconstitution following autologous bone marrow transplantation Clinical and Experimental Immunology 51(3): 455-460
Petersen, E.J.; Rozenberg-Arska, M.; Dekker, A.W.; Clevers, H.C.; Verdonck, L.F. 1996: Allogeneic bone marrow transplantation can restore CD4+ T-lymphocyte count and immune function in idiopathic CD4+ T-lymphocytopenia Bone Marrow Transplantation 18(4): 813-815
Gorin, N.C.; Labopin, M.; Meloni, G.; Korbling, M.; Carella, A.; Herve, P.; Burnett, A.; Rizzoli, V.; Alessandrino, E.P.; Bjorkstrand, B. 1991: Autologous bone marrow transplantation for acute myeloblastic leukemia in Europe: further evidence of the role of marrow purging by mafosfamide. European Co-operative Group for Bone Marrow Transplantation (EBMT) Leukemia 5(10): 896-904
Fegan, C.; Thomas, H.; Bailey-Wood, R.; Coleman, S.; Phillips, S.; Hoy, T.; Whittaker, J.A. 1995: In vitro LAK (lymphokine activated killer) activity following autologous peripheral blood stem cell is significantly greater than that following autologous bone marrow and allogeneic bone marrow transplantation Bone Marrow Transplantation 16(2): 277-281
Hernández, M.D.; del Cañizo, M.C.; González, M.; Caballero, M.D.; López-Berges, M.C.; Vázquez, L.; Orfao, A.; Corral, M.; Nieto, M.J.; San Miguel, J.F. 1998: Immune reconstitution after autologous progenitor hemopoietic cell transplantation. a study comparing autologous bone marrow and autologous peripheral blood transplantation Medicina Clinica 110(20): 768-773
Roberts, M.M.; To, L.B.; Gillis, D.; Mundy, J.; Rawling, C.; Ng, K.; Juttner, C.A. 1993: Immune reconstitution following peripheral blood stem cell transplantation, autologous bone marrow transplantation and allogeneic bone marrow transplantation Bone Marrow Transplantation 12(5): 469-475
Ozsahin, H.; Fabrega, S.; Douay, L.; Barbu, V.; Gorin, N.C. 1990: Application of serum-free liquid bone marrow cultures to bone marrow purging for autologous bone marrow transplantation in acute lymphoblastic leukemia Nouvelle Revue Francaise d'Hematologie 32(5): 353-355
Duhamel, G.; Gorin, N.C.; Douay, L.; Najman, A.; Stachowiak, J. 1982: Bone marrow repopulation after heavy chemotherapy and autologous bone marrow transplantation. Monitoring with biopsies and marrow culture on agar La Nouvelle Presse Medicale 11(11): 833-836
Richard, C.; Calavia, J.; Loyola, I.; Baró, J.; Cuadrado, M.A.; Gómez-Casares, M.T.; Zurbano, F.; Ondiviela, R.; Zubizarreta, A. 1994: Chronic eosinophilic pneumonia in a patient treated with allogenic bone marrow transplantation Medicina Clinica 102(12): 462-464
Schrøder, H.; Clausen, N.; Thorling, K.; Hokland, P. 1993: Autologous bone marrow transplantation in children with malignant diseases. Bone marrow harvest and procedure-related toxicity Ugeskrift for Laeger 155(20): 1536-1539
Bolwell, B.J.; Fishleder, A.; Andresen, S.W.; Lichtin, A.E.; Koo, A.; Yanssens, T.; Burwell, R.; Baucco, P.; Green, R. 1993: G-CSF primed peripheral blood progenitor cells in autologous bone marrow transplantation: parameters affecting bone marrow engraftment Bone Marrow Transplantation 12(6): 609-614
Oudshoorn, M.; Falkenburg, J.H.; Ebeling, L.J.; Haak, H.L.; Wijermans, P.W.; Fibbe, W.E.; Willemze, R.; van Rood, J.J. 1996: Unrelated bone marrow transplantation as a rescue procedure following inadvertent loss of an autologous bone marrow graft Bone Marrow Transplantation 18(2): 461-463
Jackson, G.H.; Clarke, A.J.; Taylor, P.; Dickinson, A.M.; Proctor, S.J.; Cattan, A.R. 1991: Supernatant cell counts from long-term bone marrow culture correlate with the speed of engraftment following autologous bone marrow transplantation Bone Marrow Transplantation 8(6): 439-444
Chang, J.; Morgenstern, G.R.; Coutinho, L.H.; Scarffe, J.H.; Carr, T.; Deakin, D.P.; Testa, N.G.; Dexter, T.M. 1989: The use of bone marrow cells grown in long-term culture for autologous bone marrow transplantation in acute myeloid leukaemia: an update Bone Marrow Transplantation 4(1): 5-9
Gulati, S.; Acaba, L.; Yahalom, J.; Reich, L.; Motzer, R.; Crown, J.; Doherty, M.; Clarkson, B.; Berman, E.; Atzpodien, J. 1992: Autologous bone marrow transplantation for acute myelogenous leukemia using 4-hydroperoxycyclophosphamide and VP-16 purged bone marrow Bone Marrow Transplantation 10(2): 129-134
Canals, C.; Picón, M.; Sanchez, T.; Torrico, C.; Amill, B.; Tugues, D.; Sierra, J.; Grañena, A.; Badell, I.; Brunet, S. 1994: Autologous bone marrow transplantation for acute lymphoblastic leukemia: role of bone marrow purging Progress in Clinical and Biological Research 389: 125-132
del Rosario Uriarte, M.; Bonomi, R.; Azambuja, C.; Seuánez, H.N. 1997: Bone marrow reconstitution with normal autologous cells demonstrated by VNTR analysis after allogeneic bone marrow transplantation for chronic myelogenous leukemia Leukemia 11(12): 2213-2214
Kessinger, A.; Vose, J.M.; Bierman, P.J.; Armitage, J.O. 1991: High-dose therapy and autologous peripheral stem cell transplantation for patients with bone marrow metastases and relapsed lymphoma: an alternative to bone marrow purging Experimental Hematology 19(10): 1013-1016
Ueda, M.; Joshi, I.D.; Dan, M.; Uberti, J.P.; Chou, T.H.; Sensenbrenner, L.L.; Lum, L.G. 1993: Preclinical studies for adoptive immunotherapy in bone marrow transplantation. Generation of anti-CD3 activated cytotoxic T cells from normal donors and autologous bone marrow transplant candidates Transplantation 56(2): 351-356