Atherosclerotic lesions in humans--plaque stabilization and regression
Kritz, H.; Sinzinger, H.
Wiener Klinische Wochenschrift 107(18): 555-566
1995
ISSN/ISBN: 0043-5325 PMID: 7483643 Document Number: 447872
Although lowering of total- and LDL-cholesterol with different methods, like dietary restrictions mostly combined with lipid-lowering drugs (monotherapy or combined drug therapy) or changes in lifestyle (e.g., cessation from smoking) have demonstrated significant clinical benefits in a number of clinical trials, the magnitude of angiographically proven regression of atherosclerotic lesions is relatively small despite aggressive lipid-lowering regimens. A potentially important therapeutic target especially for limited indications includes the use of LDL-apheresis, where functional and later morphological regression occurs.