Development and evaluation of a buccoadhesive propranolol tablet formulation
Celebi, N.; Kişlal, O.
Die Pharmazie 50(7): 470-472
1995
ISSN/ISBN: 0031-7144 PMID: 7675890 Document Number: 447739
Buccoadhesive tablets were prepared by directly compressing propranolol with poly(acrylic)acid (PAA), hydroxypropylmethylcellulose (HPMC) and hydroxypropylcellulose (HPC) in different ratios. The release data were fitted to Mt/M infinity = ktn simple equation. The release characteristics has shown a non-Fickian mechanism of release. The best kinetic fit were zero order and slab erosion kinetic. The detachment force between buccoadhesive tablets and bovine buccal mucosa was carried out by the tensile tester apparatus. The high amount of PAA containing formulation demonstrated the greatest adhesive force.