Effect of low dose recombinant human omega erythropoietin (rHuEPO) on anaemia in patients on hemodialysis
Acharya, V.N.; Sinha, D.K.; Almeida, A.F.; Pathare, A.V.
Journal of the Association of Physicians of India 43(8): 539-542
1995
ISSN/ISBN: 0004-5772 PMID: 8772973 Document Number: 447686
The effect of low dose rHuEPO therapy in ESRD patients on regular dialysis therapy was assessed in a prospective study in 22 patients. Routine hematological and biochemical tests, bone marrow aspiration, serum iron and ferritin studies were performed. The quality of life was also assessed. rHuEPO was administered in a dose of 25 units/kg i.v. post dialysis 3 times a week for 8 weeks, followed by 36 units/kg for further 4 weeks. Significant rise (p = 0.0001) in Hb & PCV with rise in reticulocyte count (0.016) was noted. Serum ferritin was a better index of iron status of the body. Significantly improved anemia and quality of life of ESRD patients on hemodialysis was seen in 95% of the patients.