Clinical differentiation between lethal catatonia and neuroleptic malignant syndrome: a case report
Terlikowska, M.; Marzański, M.
Psychiatria Polska 29(3): 343-348
1995
ISSN/ISBN: 0033-2674 PMID: 7652087 Document Number: 446906
Lethal catatonia is often regarded as clinically similar to, and perhaps indistinguishable from, neuroleptic malignant syndrome. However, the two syndromes reveal differences in the mode of onset, signs and symptoms, and outcome. Lethal catatonia often begins with extreme psychotic excitement, which, if persistent, can lead to fever, exhaustion, and death. Neuroleptic malignant syndrome begins with severe extrapyramidally induced muscle rigidity. Early clinical differentiation is important, because lethal catatonia often requires neuroleptic treatment, and neuroleptic malignant syndrome necessitates immediate cessation of neuroleptics.