The adsorbed-DTP-m vaccination of children with allergically altered reactivity
Kostinov, M.P.; Balabolkin, I.I.; Sigaeva, L.A.; Reutova, V.S.; Bogatyreva, E.I.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 1: 44-49
1995
ISSN/ISBN: 0372-9311 PMID: 7778374 Document Number: 446610
Immunization and booster immunization with adsorbed DPT-m vaccine was carried out, respectively, in 45 and 15 children with different severity of the course of an allergic disease, each child receiving simultaneously individually prescribed complex drug therapy. The postvaccinal period took a relatively favorable course. General and allergic reactions and complications observed after the injection of the preparation did not hinder the continuation of the course of immunization, while the appearance of neurological reactions provoked doubts on the expediency of the repeated injection of this preparation. A decrease in the content of diphtheria and tetanus toxoids in one immunization dose did not lead to the decreased synthesis of specific antibodies. The present investigation showed the possibility of using adsorbed DPT-m vaccine with reduced antigen content in cases of both the remission of an allergic disease and the subacute course of such disease.