Influence of gold salts treatment on the serum concentration of IL-1 and IL-2 in patients with rheumatoid arthritis
Lewandowicz, J.; Dabkowska, B.; Nowak, D.
Archivum Immunologiae et Therapiae Experimentalis 43(3-4): 195-198
1995
ISSN/ISBN: 0004-069X PMID: 8744695 Document Number: 443826
Eighteen subjects (2 males, 16 females) with rheumatoid arthritis were treated with gold salts for 6 months. The statistically significant decrease of IL-1 and IL-2 levels during the treatment was observed. The mean serum concentrations of IL-1 and IL-2 decreased from 41.0 +/- 11.5 to 28.6 +/- 7.3 (p < 0.001) and 98.3 +/- 57.6 to 29.3 +/- 20.5 fmol/ml (p < 0.001), respectively. This decrease was accompanied by a decline of serum concentration of acute phase proteins and immunoglobulins. These results can explain a strong anti-inflammatory action of gold salts in patients with rheumatoid arthritis.