Late graft failure due to dual bone marrow infection with variants A and B of human herpesvirus-6
Rosenfeld, C.S.; Rybka, W.B.; Weinbaum, D.; Carrigan, D.R.; Knox, K.K.; Andrews, D.F.; Shadduck, R.K.
Experimental Hematology 23(7): 626-629
1995
ISSN/ISBN: 0301-472X PMID: 7601254 Document Number: 443317
Hematopoietic effects of human Herpesvirus-6 (HHV-6) infection following bone marrow transplantation (BMT) include delayed engraftment and early myelosuppression. Variant A has not been isolated after BMT. A case of graft failure is reported following an HLA-identical BMT for chronic myelogenous leukemia (CML) in chronic phase. Evaluation of bone marrow during the period of graft failure revealed variants A and B of HHV-6 by culture, immunofluorescence, polymerase chain reaction (PCR), and immunohistochemistry. Evidence for other cases of graft failure, including cytomegalovirus (CMV), could not be found. A hypothesis is proposed that late graft failure in this case was due to variant A of HHV-6.