Present investigations for the development of male hormonal contraception
Bruce Schearer, S.
Estudios de Poblacion 3(7-11): 117-120
1978
PMID: 12278216 Document Number: 442769
researchers began in the early 1970s to study the development of hormonal contraceptives for men. Clinical studies with progesterone and progesterone derivates, both strong spermatogenesis-blocking agents, have given satisfactory but not excellent results. Azoospermia was never obtained, and a number of side effects were noted, such as decreased libido, increase in body weight, and also hepatic toxicity. Other studies employed androgens, especially testosterone, with less side effects, but still without ever achieving azoospermia. Ongoing studies are trying to use progesterone and androgens in a combined regimen. Preliminary data indicate the same results as with preceding studies. With male hormonal contraception reversibility is always possible although not complete till about 2 years after termination of treatment.