De/remineralization from sodium fluoride dentifrices
Wefel, J.S.; Jensen, M.E.; Triolo, P.T.; Faller, R.V.; Hogan, M.M.; Bowman, W.D.
American Journal of Dentistry 8(4): 217-220
1995
ISSN/ISBN: 0894-8275 PMID: 7576392 Document Number: 442480
To test the demineralization/remineralization effects of sodium fluoride dentifrices using an in situ single-section crown model system. A fluoride dose response was evaluated using 0, 1100 and 2800 ppm F-, along with the effects of an enhanced fluoride delivery system (polyampholyte-NaF). The single-section crown model was employed with supervised toothbrushing twice a day. At the end of each 1-month study leg, sections were removed and replaced with new sections for the next leg. Both before and after the double-blind, crossover portion of the study, sections were evaluated by polarized light microscopy and microradiography. The change in mineral content of the enamel and root lesions was analyzed by ANOVA with a Waller-Duncan K-Ratio Test post hoc. The placebo dentifrice group showed a loss of mineral and was statistically different from all groups. The fluoride dentifrices showed increasing amounts of enamel mineral gain, with increasing fluoride concentration. The polyampholyte-NaF delivery system with 1100 ppm F- was equivalent to the 2800 ppm F- dentifrice. Root lesions gave similar rank-order results although all treatments showed demineralization or mineral loss.