Review of in vivo technics in the quantification of insulin sensitivity
Mokán, M.
Vnitrni Lekarstvi 41(2): 84-91
1995
ISSN/ISBN: 0042-773X PMID: 7725645 Document Number: 441140
The ability to measure insulin sensitivity plays important role mainly in investigation of pathogenesis of noninsulin-dependent diabetes mellitus. The measurement of insulin sensitivity means to measure the insulin's effect on glucose metabolism--on hepatic glucose production and peripheral glucose uptake. From all in vivo techniques for measurement of insulin sensitivity are considered for most suitable at the present time next 2: clamp technique (euglycemic hyperinsulinemic and hyperglycemic hyperinsulinemic clamp) and Bergman's minimal model technique. Clamp methods and minimal model method are significantly correlated in vivo methods for measurement of insulin sensitivity and beta-cell secretory function as well.