Relationship between atrial natriuretic peptide (ANP) , renin (PRA) , aldosterone (PAC) , hemodynamic responses to lower body negative pressure (LBNP) and +Gz tolerance
Turski, B.K.; Gembicka-Kuzak, D.M.; Debinski, W.B.; Kuzak, W.
Journal of Gravitational Physiology a Journal of the International Society for Gravitational Physiology 2(1): P37-P38
1995
ISSN/ISBN: 1077-9248 PMID: 11538925 Document Number: 440910
The redistribution of a certain thoracic blood volume to the lower parts of the body and decrease of the venous return of blood to the heart during lower body negative pressure leads to the central hypovolemia and the deactivation of cardiopulmonary and arterial baroreceptors. Many compensatory mechanisms are involved during central hypovolemia, which is also reflected by the changes in the secretion of different vasoactive hormones. Due to this fact the LBNP stimulus is widely used for the investigation of regulatory (compensatory) mechanisms in cardiovascular system providing deeper understanding of orthostatic reaction. Recently several papers were published on application of this experimental model for +Gz acceleration tolerance assessment. The purpose of this study was evaluate the possible dependence between the changes of ANP secretion, renin-angiotensin-aldosterone system activity, the changes of some hemodynamic parameters during the model of gravitational stress i.e. LBNP exposure and +Gz acceleration tolerance.