Hereditary solitary adenoma
Yoshikawa, R.; Utsunomiya, J.
Nihon Rinsho. Japanese Journal of Clinical Medicine 53(11): 2734-2736
1995
ISSN/ISBN: 0047-1852 PMID: 8538035 Document Number: 439343
Hereditary solitary adenomas is characterized by a low number of adenomatous polyps (usually fewer than 100), but still carries an elevated risk of colon cancer. This colon cancer susceptibility disorder is believed to be inherited as an autosomal dominant. Recent molecular studies have revealed that the mutant alleles responsible for this disorder is mapped to the adenomatous polyposis coli (APC) locus on human chromosome 5q. The average age at onset for developing cancer is approximately 15 years later than that observed in classical APC and approximately 10 years earlier than patients with sporadic colorectal cancer.