Leukemia in delta-GAG-MYC transgenic mice
Shvemberger, I.N.; Ginkul, L.B.; Ermilov, A.N.
Voprosy Onkologii 40(4-6): 198-202
1994
ISSN/ISBN: 0507-3758 PMID: 7785244 Document Number: 438373
Transgenic mice carrying two DELTA-gag-myc genetic constructions were produced and kept under observation during their whole life- Nineteen out of 119 transgenic mice developed such hemopoietic diseases as lymphoid tissue hyperplasia, lymphoma, lymphosarcoma and myeloma. Lymphoid tissue hyperplasia and lymphoma generally involved multiple hyperplastic and neoplastic pathologies which were regarded, on the whole, as "malignant disease". In all cases, lymphosarcoma and myeloma were the only deadly pathologies. Lymphomas and myelomas were detected after 3-9 months, lymphosarcomas - 18-29 months while lymphoid tissue hyperplasia occurred virtually throughout the entire life span - 3-31 months. The study has shown that transgenic mice carrying DELTA-gag-myc gene in their genome can be used in the designing of special models for investigations of certain patterns of leukemia.