HLA and disease: past, present and future
de Vries, R.R.
Netherlands Journal of Medicine 45(6): 302-308
1994
ISSN/ISBN: 0300-2977 PMID: 7838247 Document Number: 438306
This review on human leukocyte antigens (HLA) and disease associations is divided into three parts: past, present and future. In the first part the HLA system and its (main) function are presented in an historical perspective. The second part discusses the associations between HLA alleles and disease susceptibility with their present applications and implications. In the last part it is speculated that the molecular basis of the association between HLA Class II and at least one immunopathological disease will be unravelled in the near future and that this may result in new immunopreventive and immunotherapeutic strategies.