The comparative efficacy of verapamil, nifedipine and propranolol in patients with IHD and an enhanced risk of a fatal outcome
Mazur, N.A.; Pavlova, T.S.; Vasil'eva, N.N.; Kul'ginskaia, I.V.
Terapevticheskii Arkhiv 66(8): 26-30
1994
ISSN/ISBN: 0040-3660 PMID: 7527161 Document Number: 437975
In a randomized controlled trial 329 postmyocardial infarction patients with high-grade ventricular extrasystoles were divided into 3 groups. Group 1 of 112 patients received calcium antagonists (verapamil, nifedipine, verapamil+nifedipine), group 2 of 100 patients received propranolol hydrochloride, group 3 consisted of 117 controls. The aim of the study was to elucidate the effect of the above drugs on sudden death and repeated nonfatal infarction risk. The mean follow-up duration made up 16 +/- 0.9, 16.8 +/- 1.1, 20.8 +/- 1.0 months for groups 1,2 and 3, respectively. 35 patients of the treatment groups turned out inappreciable because of early discontinuation of chemotherapy. Overall lethality for the groups 1, 2 and 3 reached 0.9%, 4% and 12% of patients, respectively. Most of lethal outcomes in the controls were sudden. Repeated nonfatal myocardial infarction arose less frequently in groups 1 and 2, but the difference was insignificant.