Smoking and industrial pollution, and their effects on menopause and ovarian cancer

Mattison, D.R.; Thorgeirsson, S.S.

Lancet 1(8057): 187-188

1978


ISSN/ISBN: 0140-6736
PMID: 74610
DOI: 10.1016/s0140-6736(78)90617-7
Document Number: 437939
The rodent-ovary contains an enzyme system(s) capable of metabolizing polycyclic aromatic hydrocarbons to reactive electrophilic intermediates known to cause cytotoxicity, mutation and cancer. If the human ovary contains similar enzyme systems, metabolic activation of environmental chemicals could explain the earlier menopause in cigarette smokers and the higher incidence of ovarian cancer in industrialized areas.

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