Smoking and industrial pollution, and their effects on menopause and ovarian cancer
Mattison, D.R.; Thorgeirsson, S.S.
Lancet 1(8057): 187-188
1978
ISSN/ISBN: 0140-6736 PMID: 74610 DOI: 10.1016/s0140-6736(78)90617-7Document Number: 437939
The rodent-ovary contains an enzyme system(s) capable of metabolizing polycyclic aromatic hydrocarbons to reactive electrophilic intermediates known to cause cytotoxicity, mutation and cancer. If the human ovary contains similar enzyme systems, metabolic activation of environmental chemicals could explain the earlier menopause in cigarette smokers and the higher incidence of ovarian cancer in industrialized areas.
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