Studies on magnetic responsiveness and renal embolization with magnetic microspheres in dogs
Wu, C.B.; Wei, S.L.; Lu, W.; Zhao, Y.L.; Gao, W.W.
Yao Xue Xue Bao 29(4): 311-315
1994
ISSN/ISBN: 0513-4870 PMID: 7976345 Document Number: 437177
The responsiveness and transcatheter embolization with magnetic gelatin microspheres (MG-ms) in dogs kidney were reported. In experiments with magnet using a constant flow apparatus such as roller pump, the percent retention was determined by counting the carrier retained by the magnetic field and divided by the total starting counts. Factors influencing the percent retention of MG-ms include: velocity of medium flow, magnetic field intensity, alpha-Fe-2O-3 content in the MG-ms, viscosity of the medium and so on. Transcatheter embolization with MG-ms (10 apprx 30 mu-m) was performed under external magnet control in dog kidney. The result of angiogram and histological section showed that the Mg-ms were in the arteries, arterioles, and glomerular capillaries with no adverse reactions. These results show that the MG-ms is a promising embolic agent for treatment of renal cancer under external magnet control.