The chronobiological aspects of drug resistance to antianginal therapy
Arushanian, E.B.; Shamliian, T.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 57(4): 33-35
1994
ISSN/ISBN: 0869-2092 PMID: 7950781 Document Number: 436874
Two groups of ischemic heart disease patients with different responses to antianginal therapy (propranolol, nifedipine) were studied. Mathematical analysis of heart rate variabilities showed that tolerant patients had a low index of centralization, lack of its circadian rhythm and a low correlation between several cardiointervalographic parameters. Bearing in mind these shifts makes it possible to predict the therapeutical efficiency of the antianginal drugs.
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