Directions in the development of postsynaptic nondepolarizing muscle relaxants with rapidly developing action
Danilov, A.F.; Zhabko, E.P.; Fedorov, I.D.
Eksperimental'naia i Klinicheskaia Farmakologiia 57(4): 18-20
1994
ISSN/ISBN: 0869-2092 PMID: 7950774 Document Number: 435890
The experiments on unconscious cats have shown that the myoparalytic effect of postsynaptic non-depolarizing myorelaxants which have a trimethylammonium cationic group develops more rapidly than that of their triethylammonium analogues. The compound IEM-1213 is given as an example of a trimethylammonium derivative with the rigid structure of the molecule having an unusual rapidly developed effect.