Comparison of a mixture of papaverine, phentolamine and prostaglandin E1 with other intracavernous injections
Meinhardt, W.; Lycklama à Nijeholt, A.A.; Kropman, R.F.; Vermeij, P.; Zwartendijk, J.
European Urology 26(4): 319-321
1994
ISSN/ISBN: 0302-2838 PMID: 7713130 Document Number: 435837
Objective: evaluation of a self-injection program with a mixture of papaverine, phentolamine and prostaglandin E-1 (PGE-1). Method: a self-injection program for erectile dysfunction was started by 48 patients, using a 1-ml mixture of 4.5 mg papaverine, 0.2 mg phentolamine and 1.5 mu-g PGE-1. Patients completed a questionnaire at 6 weeks and at 3 months and were followed at the Outpatients Department for an average of 1 year. Result: of these patients 25 had previous experience with 20 mu-g PGE, for intracavernous use and 22 patients had previously used 30 mg papaverine with 1 mg phentolamine. None of these 3 self-injection drugs is obviously superior in its ability to induce erections. Priapism occurred twice on a total of 1,290 injections. After 1-year follow-up, 4 patients had developed problems with fibrosis of the corpora, 2 of whom had encountered this problem also in a previous self-injection program. Conclusion: this triple mixture has the disadvantage of causing fibrosis and priapism in susceptible patients.