Plasmodium vivax: immune responses in a cross-section of the population in the Delhi area of India
Ray, P.; Ansari, M.A.; Sharma, Y.D.
American Journal of Tropical Medicine and Hygiene 51(4): 436-443
1994
ISSN/ISBN: 0002-9637 PMID: 7943570 Document Number: 435744
The immune status of the individuals living in the Delhi area of northern India where Plasmodium vivax is predominant is described. The majority of the individuals who were acutely infected with P. vivax had antibodies against crude blood-stage antigen and the recombinant antigen, PV9. In contrast, the peripheral blood mononuclear cells of the majority of these individuals did not show proliferation in the presence of either of these antigens. There was no correlation between antibody levels and T cell proliferation. Such an immune status of individuals living in endemic areas should be taken into account in the future in developing P. vivax malaria vaccines.