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Detecting and monitoring trophoblastic disease. New perspectives on measuring human chorionic gonadotropin levels

Cole, L.A.; Kohorn, E.I.; Kim, G.S.

Journal of Reproductive Medicine 39(3): 193-200

1994

ISSN/ISBN: 0024-7758
PMID: 8035374
Document Number: 435609
The human chorionic gonadotropin (hCG) molecules in trophoblastic disease serum and urine samples are more heterogeneous, or degraded, than those in pregnancy samples. HCG immunoassays, particularly some of the new multiantibody sandwich tests, are designed primarily for pregnancy application and do not necessarily detect the degraded molecules found in trophoblastic disease samples. This leads to erroneous results and possibly false diagnoses. Care is needed in choosing the hCC test for monitoring trophoblastic disease.

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