Estrogen secretion and cellular source of ovarian epithelial tumors
Yin, J.Z.; Kuang, J.Q.
Zhonghua Fu Chan Ke Za Zhi 29(2): 82
1994
ISSN/ISBN: 0529-567X PMID: 8033631 Document Number: 434830
This paper studies the estrogen secretion of ovarian epithelial tumors in postmenopausal women by using the radioimmunoassay method to measure the concentration of estradiol (E2) in peripheral and ovarian venous blood, using the immunohistochemical method (ABC) to locate the cell position of E2 in tumor tissue, and observing the clinical symptoms of the patients. The results demonstrated that epithelial ovarian tumors in postmenopausal women can secret E2 and the secretory function of mucinous tumor is most active in epithelial ovarian tumors; the E2 produced by the tumors is not only from the stromal cells of the tumors, but mainly from the epithelial cells of the tumors. The secretory function of E2 is usually manifested in "the subclinical condition", but sometimes it may show clinical symptoms. So, epithelial ovarian tumors should be considered when women have the symptom of postmenopausal uterine bleeding.