The effect of changes in the cultivation conditions on the amplification of different Mycoplasma pneumoniae genes
Zigangirova, N.A.; Rakovskaia, I.V.; Gintsburg, A.L.; Prozorovskiĭ, S.V.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii Suppl 1: 40-44
1994
ISSN/ISBN: 0372-9311 PMID: 7856348 Document Number: 434557
In experiments carried out with the use of the polymerase chain reaction the inhibition of the amplification of several regions of M. pneumoniae genome, depending on the conditions of their cultivation, has been observed. We suggest that protein, selectively binding with individual sites of DNA, is capable of inhibiting the expression of genes coding pathogenicity factors and thus contributes to the transformation of mycoplasmas into persistent forms.