Biochemical study of the A2F4 antigen associated with human pulmonary adenocarcinoma

Gorbachev, A.V.; Egorova, S.G.; Miagkov, A.V.; Gorbachev, A.V; Egorova, S.G; Miagkov, A.V

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Biochemical study of the A2F4 antigen associated with human pulmonary adenocarcinoma

Gorbachev, A.V.; Egorova, S.G.; Miagkov, A.V.

Biokhimiia 59(9): 1401-1405

1994

ISSN/ISBN: 0320-9725

PMID: 7819415

Document Number: 433363

The tissue-specific antigen associated with human lung adenocarcinoma had been investigated using immunological and biochemical methods. The antigen, which represents a new tissue-specific marker, has a molecular weight of 400 kDa. Purification of the antigen was achieved by gel chromatography. Antibody binding to the antigen was studied using enzyme-linked immunoassay after preincubation with enzymes or treatment with periodate. The results obtained testify to the proteinaceous nature of the antigenic determinant and the glycoprotein nature of the antigen.