Effects of methylprednisolone on functional recovery of stunned myocardium in dogs
Nakayama, M.; Fujita, S.; Kanaya, N.; Tuchida, H.; Namiki, A.
Masui. Japanese Journal of Anesthesiology 43(11): 1722-1726
1994
ISSN/ISBN: 0021-4892 PMID: 7861606 Document Number: 433286
We investigated the effects of methylprednisolone (MP) on the time course of functional recovery of myocardium following 15 min of coronary artery occlusion and 1 h reperfusion (stunned myocardium) in morphine-urethane-alpha-chloralose-anesthetized dogs. Myocardial segmental shortening (%SS) in the subendocardium of ischemic areas was measured by sonomicrometry. MP (30 mg cntdot kg-1 iv) was administrated 90 min before the occlusion period. Compared with the control group, %SS in the ischemic region was significantly (P lt 0.05) greater in the MP-treated group during 15 to 60 min of the reperfusion period. There were no significant differences in other hemodynamic data between the control and MP-treated groups. In conclusion, it was shown that MP enhances the functional recovery of stunned myocardium.