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Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score

Shapiro, S.; Heinonen, O.P.; Siskind, V.; Kaufman, D.W.; Monson, R.R.; Slone, D.

American Journal of Obstetrics and Gynecology 128(5): 480-485

1977

ISSN/ISBN: 0002-9378
PMID: 879205
DOI: 10.1016/0002-9378(77)90028-x
Document Number: 432952
The effects of doxylamine succinate (DAS) and dicylomin hydrochloride (DHC), each of which is contained in the drug Bendectin, administration during pregnancy on offspring was investigated in a prospective cohort study of 50,282 women and their offspring. The overall malformaton rate was similar among 509 heavily exposed infants, 660 moderately exposed children, and 49,113 who were not exposed.Treatment also did not appear to affect mean birth weight, the rate of perinatal mortality, and intelligence quotient scores determined at 4-years of age.

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