Differences in u-PA and t-PA increase during acute exercise: relation with exercise parameters
van den Burg, P.J.; Dooijewaard, G.; van Vliet, M.; Mosterd, W.L.; Kluft, C.; Huisveld, I.A.
Thrombosis and Haemostasis 71(2): 236-239
1994
ISSN/ISBN: 0340-6245 PMID: 8191405 Document Number: 432637
Plasma levels of urokinase-type (u-PA Ag) and tissue-type (t-PA Ag) plasminogen activator are both enhanced during physical exercise. Whether, the extent of the increase and the post-exercise clearance rate of the two activators are comparable is not known. We studied the changes in u-PA Ag, t-PA Ag and t-PA activity during a standardized exercise test comprising submaximal and maximal exercise intensity. During submaximal (recreational) exercise, increases in u-PA are mainly due to changes in plasma volume, submaximal exercise demonstrates a continuous rise in level of t-PA Ag. During maximal performance peak levels of u-PA and t-PA Ag do not coincide in time and magnitude, moreover, u-PA Ag rather than t-PA Ag is related to t-PA Act. From these results we conclude that independent mechanisms regulate the exercise-induced plasma levels of u-PA and t-PA.