Nabumetone, an effective anti-inflammatory agent, lacks gastrointestinal irritancy in the rat when dosed orally for one month: comparison with tiaprofenic acid and etodolac
Melarange, R.; Gentry, C.; Blower, P.R.; Toseland, C.D.; Spangler, R.
European Journal of Rheumatology and Inflammation 14(2): 15-22
1994
ISSN/ISBN: 0140-1610 PMID: 7744129 Document Number: 432109
Objective: To determine the effects of nabumetone, compared with tiaprofenic acid and etodolac, on anti-inflammatory efficacy and gastrointestinal irritancy in the rat when dosed orally for one month at a high anti-inflammatory dose. Methods: Carrageenan paw edema was used as a model of inflammation. Gastrointestinal mucosal integrity was assessed by concurrently measuring ulcer formation, mucosal and tissue prostanoid production and plasma haptoglobin. Haemoglobin, present in the cecal contents, was used as a measure of blood loss. Results: Nabumetone, tiaprofenic acid and etodolac inhibited inflammation. Etodolac induced marked gastrointestinal damage and blood loss whereas tiaprofenic acid caused only gastric damage. Nabumetone was found not to alter mucosal integrity. Conclusion: Nabumetone proved to be an effective anti-inflammatory agent that was devoid of gastrointestinal irritancy.