Tacalcitol ointment for psoriasis
Nishimura, M.; Makino, Y.; Matugi, H.
Acta Dermato-Venereologica. Supplementum 186: 166-168
1994
ISSN/ISBN: 0365-8341 PMID: 8073825 Document Number: 432094
Transdermal absorption of tacalcitol from the ointment containing 2 micrograms/g was studied using hairless rat and human skin. In the animal experiments, a non-negligible amount of tacalcitol was absorbed transdermally, whereas in the case of human skin, this compound was hardly absorbed at all. A placebo-controlled double-blind right/left comparison confirmed that this ointment is effective and safe for the treatment of psoriasis.
Document emailed within 1 workday
Related Documents
Miyachi, Y.; Ohkawara, A.; Ohkido, M.; Harada, S.; Tamaki, K.; Nakagawa, H.; Hori, Y.; Nishiyama, S. 2002: Long-term safety and efficacy of high-concentration (20 microg/g) tacalcitol ointment in psoriasis vulgaris European Journal of Dermatology: Ejd 12(5): 463-468Kole, L.; Cantrell, W.; Elewski, B. 2014: A randomized, double-blinded trial evaluating the efficacy and tolerability of vectical ointment (calcitriol 3 mcg/g ointment) when compared to betamethasone diproprionate ointment (64 mg/g) in patients with nail psoriasis Journal of Drugs in Dermatology: Jdd 13(8): 912-915
Strumia, R.; Altieri, E.; Romani, I.; Bettoli, V.; Negrini, A.; Trimurti, S. 1994: Tacalcitol in psoriasis: a video-microscopy study Acta Dermato-Venereologica. Supplementum 186: 85-87
Hellgren, L. 1976: Induction of generalized pustular psoriasis by topical use of betamethasone-dipropionate ointment in psoriasis Annals of Clinical Research 8(5): 317-319
Jacobson, C.; Cornell, R.C.; Savin, R.C. 1986: A comparison of clobetasol propionate 0.05 percent ointment and an optimized betamethasone dipropionate 0.05 percent ointment in the treatment of psoriasis Cutis 37(3): 213-4 216 218-20
Medansky, R.S.; Bressinck, R.; Cole, G.W.; Deeken, J.H.; Ellis, C.N.; Guin, J.D.; Herndon, J.H.; Lasser, A.E.; Leibsohn, E.; Menter, M.A. 1988: Mometasone furoate ointment and cream 0.1 percent in treatment of psoriasis: comparison with ointment and cream formulations of fluocinolone acetonide 0.025 percent and triamcinolone acetonide 0.1 percent Cutis 42(5): 480-485
Duweb, G.; Aldebani, S.; Elzorghany, A.; Benghazil, M.; Alhaddar, J. 2003: Calcipotriol ointment versus cream in psoriasis vulgaris International Journal of Clinical Pharmacology Research 23(2-3): 47-51
Duweb, G.A.; Abuzariba, O.; Rahim, M.; al-Taweel, M.; al-Alem, S.; Abdulla, S.A. 2001: Occlusive versus nonocclusive calcipotriol ointment treatment for palmoplantar psoriasis International Journal of Tissue Reactions 23(2): 59-62
Lahfa, M.; Mrowietz, U.; Koenig, M.; Simon, J.C. 2003: Calcitriol ointment and clobetasol propionate cream: a new regimen for the treatment of plaque psoriasis European Journal of Dermatology: Ejd 13(3): 261-265
Rivard, J.; Janiga, J.; Lim, H.W. 2006: Tacrolimus ointment 0.1% alone and in combination with medium-dose UVA1 in the treatment of palmar or plantar psoriasis Journal of Drugs in Dermatology: Jdd 5(6): 505-510
Pinheiro, N. 1997: Comparative effects of calcipotriol ointment (50 micrograms/g) and 5% coal tar/2% allantoin/0.5% hydrocortisone cream in treating plaque psoriasis British Journal of Clinical Practice 51(1): 16-19
Singh, P.; Gupta, S.; Abidi, A.; Krishna, A. 2013: Comparative evaluation of topical calcipotriol versus coal tar and salicylic acid ointment in chronic plaque psoriasis Journal of Drugs in Dermatology: Jdd 12(8): 868-873
Wong, J.W.; Nguyen, T.V.; Bhutani, T.; Koo, J.Y.M. 2012: Treatment of psoriasis and long-term maintenance using 308 nm excimer laser, clobetasol spray, and calcitriol ointment: a case series Journal of Drugs in Dermatology: Jdd 11(8): 994-996
Menter, A.; Abramovits, W.; Colón, L.E.; Johnson, L.A.; Gottschalk, R.W. 2009: Comparing clobetasol propionate 0.05% spray to calcipotriene 0.005% betamethasone dipropionate 0.064% ointment for the treatment of moderate to severe plaque psoriasis Journal of Drugs in Dermatology: Jdd 8(1): 52-57
Lebwohl, M.; Menter, A.; Weiss, J.; Clark, S.D.; Flores, J.; Powers, J.; Balin, A.K.; Kempers, S.; Glinert, R.J.; Fleming, T.; Liu, Y.; Graeber, M.; Pariser, D.M. 2007: Calcitriol 3 microg/g ointment in the management of mild to moderate plaque type psoriasis: results from 2 placebo-controlled, multicenter, randomized double-blind, clinical studies Journal of Drugs in Dermatology: Jdd 6(4): 428-435
Hudson, C.P.; Kempers, S.; Menter, A.; Papp, K.; Smith, S.; Sofen, H.; Colón, L.E.; Johnson, L.A.; Gottschalk, R. 2011: An open-label, multicenter study of the efficacy and safety of a weekday/weekend treatment regimen with calcitriol ointment 3 microg/g and clobetasol propionate spray 0.05% in the management of plaque psoriasis Cutis 88(4): 201-207
Horsch, W. 1984: Transport mechanism and influencing factors on the ointment-skin and drug-ointment systems Die Pharmazie 39(9): 598-605
Dang, Y.; Yang, L.; Jia, Y.; Zhu, D. 2019: Clinical efficacy of mucopolysaccharide polysulfate ointment combined with desonide ointment in treatment of infantile eczema Pakistan Journal of Pharmaceutical Sciences 32(3 Special): 1423-1426
Wananukul, S.; Limpongsanuruk, W.; Singalavanija, S.; Wisuthsarewong, W. 2006: Comparison of dexpanthenol and zinc oxide ointment with ointment base in the treatment of irritant diaper dermatitis from diarrhea: a multicenter study Journal of the Medical Association of Thailand 89(10): 1654-1658
Günzel, P.; Siegmund, F.; Bhargava, A.S.; El Etreby, M.F.; Lang, R.; Poggel, H.A.; Schöbel, C.; Schuppler, J.; Staben, P. 1977: Experimental toxicity studies on fluocortin butylester in the forms of pure active principle, ointment, fatty ointment and cream in animals Arzneimittel-Forschung 27(11a): 2217-2221