Biochemistry of bone matrix
Otawara-Hamamoto, Y.
Nihon Rinsho. Japanese Journal of Clinical Medicine 52(9): 2239-2245
1994
ISSN/ISBN: 0047-1852 PMID: 7967062 Document Number: 432084
Bone matrix proteins can be divided into several groups according to their function; structural proteins, cell adhesive molecules, growth factors, proteinases and others. 1) Type I collagen is a major structural protein. 2) Osteopontin and bone sialoprotein (BSP) are RGD-containing cell adhesive proteins. Cadherins, OSF-2 and MGP also act as cell adhesive molecules in cell to cell or cell to matrix signal transition systems. 3) BMPs, TGF-b, IGFs, FGFs and PDGF are bone growth factors associated to bone matrix. 4) Collagenases and cathepsins are well known organic bone matrix degrading enzymes.