Studies on peripheral actions of isatin
Hota, D.; Acharya, S.B.
Indian Journal of Experimental Biology 32(10): 710-717
1994
ISSN/ISBN: 0019-5189 PMID: 7821981 Document Number: 431621
The possible peripheral actions of isatin were studied in vivo and in vitro preparations in different experimental models, using conventional techniques. The results showed spasmogenic responses of isatin on guinea pig, rat and rabbit ileum and fundus of rat stomach. Histamine induced broncho-constriction could be antagonised by isatin. Isatin had cardioinhibitory effect on isolated frog heart and had hypotensive and respiratory depressant activities in dog. Isatin had antidiuretic effect. It was devoid of any effect on inflammation and gastric activities. The present results suggest a possible involvement of heterogenic 5-HT-3 receptors in gastrointestinal smooth muscle.