Planar cardiac F-18 fluorodeoxyglucose imaging with a conventional gamma camera
Kalff, V.; Van Every, B.; Lambrecht, R.M.; Rowe, J.L.; Barton, H.J.; Leaney, P.; Jamieson, C.R.; Kelly, M.J.
Medical Journal of Australia 161(7): 413-417
1994
ISSN/ISBN: 0025-729X PMID: 7935094 Document Number: 431437
Objective: To examine the potential of an adapted gamma camera to image cardiac uptake of the positron emitting glucose analogue fluorine-18 fluorodeoxyglucose (FDG). Design: Postprandial studies were performed in 19 patients (mean age, 56 +- 9 years) with coronary disease and resting cardiac dysfunction who had undergone a routine clinical 7 min/view planar thallium-201 (T1-201) stress reinjection or rest redistribution study. A glucose/insulin protocol was used and, an hour after FDG injection, 15-minute static planar myocardial images were acquired in the four views used for T1-201 scanning. Results: The diagnostic quality of FDG images was at least as good as that of their T1-201 counterparts, with less liver background in all but one FDG study. In the left anterior oblique 45 degree view uncorrected global myocardial FDG and stress T1-201 counts were similar, but the FDG study had significantly higher peak myocardial to background ratios. Conclusion: Assessing regional cardiac FDG uptake and myocardial perfusion seems feasible with conventional gamma camera technology, providing a widely available and cost effective means of detecting hibernating myocardium. Similar equipment may appreciably reduce the need for positron emission tomography in a range of clinical conditions.