Antibiotic susceptibility of streptococci isolated from blood from neutropenic patients
Piérard, D.; de Meyer, A.; Lauwers, S.
Pathologie-Biologie 42(5): 471-474
1994
ISSN/ISBN: 0369-8114 PMID: 7824316 Document Number: 430392
MICs were performed on 62 streptococci isolated from the blood of neutropenic patients from 1986 to 1992 using the NCCLS broth microdilution procedure. Species isolated were 43 S. mitis, 6 S. pneumoniae, 5 S. sanguis, 1 S. pyogenes, 1-beta-hemolytic streptococcus of the group G, 1 S. adjacens, 1 S. intermedius, 4 not identified isolates (2-alpha-hemolytic, 1 non-hemolytic and 1 nutritionally variant strains). 26% of all strains were resistant or intermediate to penicillin (MIC 90 : 2 mg/l) and 89% to norfloxacine (MIC 90 : 32 mg/l). All were susceptible to vancomycin. Among cephalosporins, all strains were susceptible to cefotaxime (MIC 90 : 1 mg/l), ceftriaxone (MIC 90 : 1 mg/l) and cefepime (MIC 90 : 2 mg/l) while 19% were R or I to ceftazidime (MIC 90 : 16 mg/l). All were susceptible to imipenem (MIC 90: 0,5 mg/l) and meropenem (MIC 90 : 1 mg/l). Among the third generation cephalosporins, ceftazidime - the agent of this class of antibiotics that is most often used for the empirical therapy of febrile episodes in neutropenic patients (in combination but also in monotherapy) - has a high resistance rate as compared to the other compounds.