Fetal outcome after local prostaglandin E2 administration in a risk patient group--comparison of morbidity with a normal patient sample
Briese, V.; Falkert, U.; Müller, H.
Zentralblatt für Gynakologie 116(8): 474-478
1994
ISSN/ISBN: 0044-4197 PMID: 7941817 Document Number: 429939
Intracervical application of prostaglandin E2 gel is considered to be effective in the induction of cervical ripening (priming). Within an 2-years period 244 perinatal risk patients primed with PGE2 were compared with matched paired controls retrospectively. These 244 controls were matched for age, gestational age, parity, birth weight and maternal body mass index and delivered spontaneously. PGE2 gel (Prepidil) was administered intracervically. Basis criteria of perinatal quality, such as neonatal umbilical cord pH and APGAR-score were significantly (p < 0.01) worse in the patients treated with PGE2 gel. In the priming group cord pH was 7.28 (+/- 0.085) and 7.30 (+/- 0.070) in the control group. APGAR 1 min. was found to be 7.56 +/- 1.86 (priming) and 8.18 +/- 1.23 (control); APGAR 5 min. 8.56 +/- 0.90 (priming) and 8.78 +/- 0.54 (control). Contraction disorders, such as hyperactivity and dyscoordination, combined with cardiotocographic pathology was found in 42% (priming) and 19% (control) resp. Severe bradycardia occurred significantly more often in the priming group, whereas no differences were found concerning fever under labor and in puerperium.