Radiation and apoptosis
Yamada, T.; Ohyama, H.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 21(5): 602-607
1994
ISSN/ISBN: 0385-0684 PMID: 8154885 Document Number: 429662
Apoptosis is a kind of programmed cell death, that is, intrinsically programmed "cell suicide process". Mammalian thymic lymphocytes, thymocytes, show a typical apoptosis immediately after a low dose irradiation. Apoptosis appears also during radiotherapy of tumor, especially of thymoma. Tumor suppressor gene such as p53 and oncogene such as bcl-2 are found to be closely related to apoptotic processes in a cell. Possible mechanisms underlying interrelationship between expression of these genes, apoptosis and carcinogenesis were discussed.
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