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Effect of excessive fluoride intake on mental work capacity of children and a preliminary study of its mechanism

Li, Y.; Li, X.; Wei, S.

Hua Xi Yi Ke Da Xue Xue Bao 25(2): 188-191

1994

ISSN/ISBN: 0257-7712
PMID: 7528715
Document Number: 429514
We made an investigation in 157 children, aged 12-13, born and grew up in a coal burning pattern endemic fluorosis area and an experiment on excessive fluoride intake in rat. The results showed: (1) Excessive fluoride intake since early childhood would reduce mental work capacity (MWC) and hair zinc content; (2) The effect on zinc metabolism was a mechanism of influence on MWC by excessive fluoride intake; (3) Excessive fluoride intake decreased 5-hydroxy indole acetic acid and increased norepinephrine in rat brain; whether this is also a mechanism of the influence on MWC awaits confirmation.

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