Spectrum of DNA haplotypes and beta-thalassemia mutations linked with them in the Azerbaijan Republic
Tagiev, A.F.; Surin, V.L.; Luk'ianenko, A.V.; Kulieva, E.A.; Mamedova, T.A.; Solov'ev, G.I.
Genetika 30(4): 535-538
1994
ISSN/ISBN: 0016-6758 PMID: 8045401 Document Number: 428648
Haplotyping of the beta-globin gene cluster was performed on DNA samples from 110 Azerbaidzhanian beta-thalassemic patients and their families. During this study, we found 18 different haplotypes and determined the frequency of their occurrence. Nine of these haplotypes have never been observed earlier in the studied population. One of the haplotypes was found only in beta-thalassemia alleles. Several haplotypes were associated with beta-thalassemia mutations found earlier in Azerbaidzhan.
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