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Lactate dehydrogenase isozyme profile in gastric mucosa as an early marker of possible neoplastic pathology in children with chronic gastroduodenal diseases

Aleksandrova, V.A.; Privorotskiĭ, V.F.

Voprosy Onkologii 40(4-6): 176-180

1994

ISSN/ISBN: 0507-3758
PMID: 7785240
Document Number: 428485
The lactate dehydrogenase (LDH) isoenzyme profile was studied in bioptic samples of gastric mucosa taken from 57 infantile patients suffering from chronic gastroduodenal pathology and 7 children with gastric functional disorders. The investigation showed LDH1 level to decrease and that of LDH5 to increase, the LDH5/LDH1 ratio increasing accordingly, in cases of erosive gastro-like gastroduodenitis and duodenal ulcers. The degree of said changes was found to correlate with the extent of morphological lesions of gastric mucosa and the most pronounced changes were recorded in cases of gastric mucosa gland atrophy. Similar changes in LDH isoenzyme profile had been identified in patients with gastric tumors. Said findings may be used in identification of groups at high risk for gastric carcinoma.

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