A correlative approach for the identification of antimutagens that demonstrate chemopreventive activity
Shamon, L.A.; Chen, C.; Mehta, R.G.; Steele, V.; Moon, R.C.; Pezzuto, J.M.
Anticancer Research 14(5a): 1775-1778
1994
ISSN/ISBN: 0250-7005 PMID: 7847810 Document Number: 428465
Seventy natural and synthetic compounds were tested for potential to inhibit mutation induced by 7,12-dimethylbenz(a)anthracene (DMBA) in Salmonella typhimurium strain TM677. Results were compared with their ability to inhibit DMBA-induced preneoplastic lesions in a mouse mammary gland organ culture system. The response mediated by fifty-five of the test compounds was either positive or negative in both test systems, indicating that the combined use of these assays should aid in the discovery of antimutagenic agents that have cancer chemopreventive potential.