Antibacterial activities of a carbapenem antibiotic, biapenem (L-627) , against penicillin-resistant Streptococcus pneumoniae
Meguro, H.; Tamura, M.; Noguchi, H.; Hayakawa, M.; Inomata, H.; Terashima, I.; Kurosaki, T.; Toba, T.
Japanese Journal of Antibiotics 47(12): 1685-1690
1994
ISSN/ISBN: 0368-2781 PMID: 7877250 Document Number: 427702
Antibiotic susceptibilities were evaluated for 48 strains of Streptococcus pneumoniae collected in 1992 apprx 1993 at Ichihara City of Chiba Prefecture. Twenty two (46%) of the 48 strains were benzylpenicillin (PCG) insensitive or resistant (PRSP) judged from the MICs of PCG to higher than 0.1 mu-g/ml. MICs of piperacillin and cefotaxime increased as the MICs of PCG increased. However, elevations of MICs of imipenem and biapenem (L-627) were small in spite of the increases of MICs of PCG. L-627 was effective in a case of purulent meningitis due to PC-insensitive S. pneumoniae. Thus, L-627 is a candidate to be used in treatment of PRSP infections including purulent meningitis.