Periodical blood pressure variation during cardiopulmonary bypass--effects of cervicothoracic epidural anesthesia and phentolamine
Sasano, H.; Sasano, N.; Ishida, S.; Oda, N.; Miura, M.; Baba, E.; Yamada, M.; Moriya, T.; Takamiya, T.; Hayano, J.
Masui. Japanese Journal of Anesthesiology 43(10): 1454-1460
1994
ISSN/ISBN: 0021-4892 PMID: 7815693 Document Number: 427668
We studied the effects of cervicothoracic epidural anesthesia or intravenous phentolamine on periodical blood pressure variation during cardiopulmonary bypass in 12 adult patients undergoing open heart surgery under fentanyl anesthesia. Spontaneous periodical fluctuation of the blood pressure was analyzed by means of autoregressive power spectrum method. Amplitudes of the low frequency (0.02-0.15 Hz) component of the blood pressure variation amplitudes were calculated. The amplitudes decreased significantly 10 minutes after cervicothoracic epidural block with 15 ml of 2% lidocaine solution (P lt 0.05), and after infusion of 0.4 mg cntdot kg-1 of phentolamine (P lt 0.05). Since amplitudes of the blood pressure variation were reduced by adequate epidural block or phentolamine, they are likely to reflect sympathetic vasomotor activity.