Demonstration of molecular combinations of alpha cyclodextrin (ACD) with dioctanoyl glycerol
Fauvelle, F.; Idiri, M.; Debouzy, J.C.
Annales Pharmaceutiques Francaises 52(5): 240-247
1994
ISSN/ISBN: 0003-4509 PMID: 7857032 Document Number: 427576
The molecular association of dioctanoyl glycerol (DOG) with the natural alpha cyclodextrin molecule (ACD) was studied using small unilamellar vesicles (SUV) by proton and 13C NMR. While no classic inclusion complex was found, a molecular association exists, leading to the formation of an insoluble precipitate. The possibility of a polar head group implication is discussed about the dimyristoyl phosphatidyl choline model.
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