The role of p53 in tumor progression
Blondal, J.A.; Benchimol, S.
Seminars in Cancer Biology 5(3): 177-186
1994
ISSN/ISBN: 1044-579X PMID: 7948946 Document Number: 427541
p53 mutation is a common event in tumors. The evidence that such mutation is an important step in the sequence of genetic changes which underly tumor progression is outlined. Such evidence includes the study of human tumors, animal tumor models and cell culture. In several instances, p53 mutation seems to be a late event. This is by no means a universal finding, and important reservations are stated concerning the role of p53 mutation in tumor progression.
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