Ways of finding inhibitors of HIV reproduction among nucleotides
Kraevskiĭ, A.A.
Molekuliarnaia Biologiia 28(6): 1245-1257
1994
ISSN/ISBN: 0026-8984 PMID: 7885326 Document Number: 427483
In spite of continuous broad search for inhibitors of HIV reproduction among new nucleosides, there seems to be a certain crisis in the problem. One of the probable solutions could be based on the investigation of nucleotide and/or nucleoside 5'-triphosphates with modified carbohydrate and phosphate residues. The review analyzes the current state of the problem, examining of such types of compounds in cell-free systems with DNA polymerases and in HIV-infected cell cultures. The known data on the stability and metabolism of such compounds in cell cultures as well as in human serum are also analyzed.