A new view of estradiol biotransformation in the body. Estradiol metabolism in the erythrocytes via the peroxidase reaction
Petrenko, I.M.; Matiushin, A.I.; Titov, V.I.
Eksperimental'naia i Klinicheskaia Farmakologiia 57(4): 45-49
1994
ISSN/ISBN: 0869-2092 PMID: 7950785 Document Number: 426971
The study has established that in the presence of horseradish peroxidase, estradiol was subject to oxidative destruction under the action of hydrogen peroxide via the peroxidase reaction. The stoichiometric ratio of the hydrogen peroxide consumption to estradiol oxidation is 1:1 in this peroxidase reaction. Estradiol peroxidation was found to be catalyzed by methemoglobin by the same order as in case of horseradish peroxidase. Based on these results and the fact that estradiol is bound to erythrocytes and penetrates inside, it is concluded that erythrocytic estradiol is metabolically converted via its peroxidation.